Exploring gene-edited microbiomes for transforming human health
DOI:
https://doi.org/10.52679/syncytia.2023.5krq7zKeywords:
Microbiome, Gene-editing, CRISPR-Cas9, Human health, Metabolic diseases, Gut-microbiota, Therapeutic potentialAbstract
The microbiome, a term used to describe the billions of bacteria that make up the human body, is a complex ecology. Recent scientific developments have generated optimism about the prospect of gene-editing to completely alter these microscopic inhabitant's role in human health. Exploring gene-edited microbiomes has enormous promise for treating metabolic disorders and preventing infectious illnesses. In this editorial, we explore the revolutionary potential of this developing subject and talk about the ethical issues it raises.
References
Aggarwal, N., Kitano, S., Puah, G. R. Y., Kittelmann, S., Hwang, I. Y., & Chang, M. W. (2023). Microbiome and human health: current understanding, engineering, and enabling technologies. Chemical Review, 123(1), 31-72. https://doi.org/10.1021/acs.chemrev.2c00431
Barnaba, V., & Sinigaglia, F. (1997). Molecular mimicry and T cell mediated autoimmune disease. Journal of Experimental Medicine, 185(9), 1529-1531. https://doi.org/10.1084/jem.185.9.1529
De Luca, F., & Shoenfeld, Y. (2019). The microbiome in autoimmune diseases. Clinical Experimental Immunology, 195(1), 74-85. https://doi.org/10.1111/cei.13158
Guo, C.-J., Allen, B. M., Hiam, K. J., Dodd, D., Van Treuren, W., Higginbottom, S., Nagashima, K., Fischer, C. R., Sonnenburg, J. L., Spitzer, M. H., et al. (2019). Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science, 366, eaav1282. https://doi.org/10.1126/science.aav1282
Hawasawi, Y. M., Shams, A., Theyab, A., Siddiqui, J., Barnawee, M., Abdali, W. A., et al. (2022). The state-of-the-art of gene editing and its application to viral infections and diseases including COVID-19. Frontiers in Cellular and Infectious Microbiology, 12, 869889. https://doi.org10.3389/fcimb.2022.869889
Kho, Z. Y., & Lal, S. K. (2018). The human gut microbiome – a potential controller of wellness and disease. Frontiers in Microbiology, 9, 1835. https://doi.org/10.3389/fmicb.2018.01835
Lam, K. N., Spanogiannopoulos, P., Soto-Perez, P., Alexander, M., Nalley, M. J., Bisanz, J. E., et al. (2021). Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome. Cell Reports, 37(5), 109930. https://doi.org/10.1016/j.celrep.2021.109930
Scheithauer, T. P. M., Rampanelli, E., & Nieuwdorp, M. (2020). Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes. Frontiers in Immunology, 11, 571731. https://doi.org/10.3389/fimmu.2020.571731
Zhang, X., Li, L., Butcher, J., Stintzi, A., & Figeys, D. (2019). Advancing functional and translational microbiome research using meta-omics approaches. Microbiome, 7(1), 154. https://doi.org/10.1186/s40168-019-0767-6
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Copyright (c) 2023 Pranav Bhaskar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
